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Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET ‐ CT scan
Author(s) -
Dinas Petros C.,
Nikaki Alexandra,
Jamurtas Athanasios Z.,
Prassopoulos Vassilios,
Efthymiadou Roxani,
Koutedakis Yiannis,
Georgoulias Panagiotis,
Flouris Andreas D.
Publication year - 2015
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12620
Subject(s) - body mass index , brown adipose tissue , overweight , medicine , lean body mass , obesity , physical activity , positron emission tomography , adipose tissue , endocrinology , fluorodeoxyglucose , metabolic activity , fat mass , nuclear medicine , body weight , physiology , physical therapy
Summary Objective Augmented brown adipose tissue ( BAT ) mass and activity lead to higher basic metabolic rate which is beneficial against obesity. Our aim was to investigate whether habitual (i.e. usual weekly participation) physical activity is linked with BAT activity and mass in humans, in a group of patients undergoing 18 F‐fluorodeoxyglucose positron emission tomography/computed tomography ( PET / CT ) scanning. Design Cross‐sectional study. Patients Forty patients with cancer [26 male; 14 female; age 52·7 ± 17·5; body mass index ( BMI ) 26·4 ± 4·5]. Measurements Patients completed the ‘usual week’ form of the International Physical Activity Questionnaire and underwent assessment of BAT activity/mass via 18 F‐fluorodeoxyglucose PET / CT . Results We detected a significant association between habitual physical activity ( MET s‐minute/week) and BAT activity [normalized by body weight (BW) (τ = 0·28, P = 0·02), body surface area (BSA) (τ = 0·29, P = 0·02) and lean body mass (LBM) (τ = 0·38, P = 0·002)]. We also found a significant negative relationship between BMI and BAT activity [normalized by BW (τ = −0·30, P = 0·006), BSA (τ = −0·31, P = 0·004) and LBM (τ = −0·45, P = 0·001)] as well as a significant negative relationship between age and BAT activity [normalized by LBM (τ = −0·28, P = 0·01)]. The results also indicate significant differences between low/moderate/high levels of habitual physical activity and BAT activity ( P < 0·05). Moreover, BAT activity was different across the BMI categories (normal/overweight/obese) in both sexes ( P < 0·05). Finally, BAT activity was greater in women than in men ( P < 0·05). Conclusions Increased participation in habitual physical activity is associated with higher BAT activity. Moreover, individuals with normal BMI demonstrate higher BAT activity compared to overweight and obese individuals. Finally, age is inversely linked with BAT activity, while women demonstrate higher BAT activity than men.