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Neutrophil–lymphocyte ratio is a reliable predictive marker for early‐stage diabetic nephropathy
Author(s) -
Huang Wanjing,
Huang Jinhua,
Liu Qingxing,
Lin Fuchuan,
He Zhihao,
Zeng Zhenhua,
He Lei
Publication year - 2015
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12576
Subject(s) - medicine , odds ratio , creatinine , diabetic nephropathy , diabetes mellitus , gastroenterology , logistic regression , predictive marker , stage (stratigraphy) , risk factor , neutrophil to lymphocyte ratio , endocrinology , type 2 diabetes mellitus , lymphocyte , biology , cancer , paleontology
Summary Introduction Diabetic nephropathy ( DN ) is a common complication in diabetics. Recent evidence suggests that neutrophil–lymphocyte ratio ( NLR ) affects the development and acceleration of some diabetic complications. Scholars have rarely investigated the relationship between DN and NLR . This study aims to evaluate the relationship between DN and NLR and estimate whether or not NLR is a reliable marker for early‐stage DN . Patients and methods The study included 253 patients with type 2 diabetes mellitus, 115 of whom have early‐stage DN . The control group was composed of 210 healthy age‐ and sex‐matched subjects. Results The NLR values of the patients with diabetes were significantly higher than those of the healthy controls ( P < 0·001), and the NLR values of the patients with early‐stage DN were higher than those of the patients without DN ( P < 0·001). Logistic regression analysis showed that the risk predictors of DN include NLR , creatinine, total cholesterol, systolic blood pressure, HbA1c and insulin resistance. NLR ( P = 0·004, EXP (B) = 2·088, 95% CI = 1·271–3·429) levels positively correlated with DN . The DN odds ratio increased by a factor of 2·088 (95% CI , 1·271–3·429) for every one unit increase in NLR . Conclusions Increased NLR was significantly associated with DN , and high NLR values may be a reliable predictive marker of early‐stage DN .