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Intraperitoneal insulin infusion: treatment option for type 1 diabetes resulting in beneficial endocrine effects beyond glycaemia
Author(s) -
Dijk P.R.,
Logtenberg S.J.J.,
Gans R.O.B.,
Bilo H.J.G.,
Kleefstra N.
Publication year - 2014
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12546
Subject(s) - medicine , insulin , endocrine system , diabetes mellitus , pharmacodynamics , endocrinology , type 2 diabetes mellitus , type 2 diabetes , pharmacokinetics , intensive care medicine , hormone
Summary Continuous intraperitoneal insulin infusion ( CIPII ) is a treatment option for patients with type 1 diabetes mellitus who fail to reach adequate glycaemic control despite intensive subcutaneous ( SC ) insulin therapy. CIPII has clear advantages over SC insulin administration in terms of pharmacokinetic and pharmacodynamic properties and has been shown to improve glycaemic regulation. Due to the delivery of insulin predominantly in the portal vein, as opposed to systemically, CIPII offers a unique research model to investigate the effects of insulin on endocrine and metabolic parameters in vivo . The aim of the present article is to provide an overview of the literature with respect to the effects of CIPII on glucose management, quality of life, complications and costs, with additional focus on metabolic and endocrine aspects. Finally, future use and research objectives are discussed.