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Effects of bariatric surgery on pericardial ectopic fat depositions and cardiovascular function
Author(s) -
Schinkel Linda D.,
Sleddering Maria A.,
Lips Mirjam A.,
Jonker Jacqueline T.,
Roos Albert,
Lamb Hildo J.,
Jazet Ingrid M.,
Pijl Hanno,
Smit Johannes W. A.
Publication year - 2014
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12402
Subject(s) - medicine , type 2 diabetes , endocrinology , weight loss , diabetes mellitus , cardiac function curve , cardiology , gastric bypass surgery , triglyceride , body mass index , insulin , obesity , cholesterol , gastric bypass , heart failure
Summary Objective Cardiac ectopic fat depositions are thought to play a role in the pathogenesis of cardiovascular disease ( CVD ), the main cause of death in patients with type 2 diabetes. Diet‐induced weight loss results in a decrease in cardiac ectopic fat stores, however if this is the same for surgically induced weight loss is less clear. Therefore, we assessed myocardial triglyceride ( TG ) content, pericardial fat and cardiac function in obese patients with insulin‐dependent type 2 diabetes before and 16 weeks after R oux‐en‐ Y gastric bypass ( RYGB ) surgery. Patients Ten obese patients with insulin‐dependent type 2 diabetes [40% male, age 53·7 ± 8·9 years (mean ± SD )] scheduled to undergo RYGB surgery were included. Measurements Ectopic fat accumulation and cardiovascular function were assessed with magnetic resonance ( MR ) imaging and myocardial TG content with MR spectroscopy before and 16 weeks after RYGB surgery. Results Body mass index decreased from 41·3 ± 4·3 at baseline to 34·1 ± 2·8 kg/m 2 ( P < 0·001) after 16 weeks. Glycemic control improved as well [ H b A 1c: 7·8 ± 1·1 to 6·8 ± 1·3% (62 ± 12 to 51 ± 14 m m ) ( P < 0·05)]. We did not observe an effect of the RYGB surgery on myocardial TG content, cardiac function or pulse wave velocity. There was a greater relative decrease in visceral (−35·5 ± 9·6%) as compared to subcutaneous fat volume (−25·0 ± 6·3%) and in paracardial (−17·3 ±17·2%) as compared to epicardial fat volume (−6·4 ± 6·0%). Conclusions This study shows that surgical‐induced weight loss leads to a larger decrease in paracardial than epicardial fat. Myocardial TG and cardiovascular function did not change.