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Gender dependence of serum soluble K lotho in acromegaly
Author(s) -
Sze Lisa,
Neidert Marian C.,
Bernays René L.,
Zwimpfer Cornelia,
Wiesli Peter,
Haile Sarah R.,
Brändle Michael,
Schmid Christoph
Publication year - 2014
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12385
Subject(s) - acromegaly , medicine , endocrinology , growth hormone , insulin like growth factor , hormone , growth factor , receptor
Summary Objectives In acromegaly, disease activity is biochemically assessed by growth hormone (GH) and insulin‐like growth factor‐1 ( IGF ‐1) levels. However, they are often discrepant, as several factors including gender influence their relationship. We recently found excessively high serum levels of soluble Klotho (sKl) in acromegalic patients, which depended on GH to a comparable extent as IGF ‐1. To further elucidate the relationship between GH and sK l, we examined the effect of gender on sK l in patients with untreated acromegaly. Patients and Design We determined GH, IGF‐1 and sK l in sera of 62 consecutive patients with newly diagnosed acromegaly (31 females/31 males, aged 20–85 years). Results For their given GH excess at presentation with acromegaly, females had lower IGF‐1 (490 ± 33 vs 604 ± 33 ng/ml, P = 0·02), but higher sK l [5171 ± 590 vs 3439 ± 431 pg/ml (mean ± SE), P = 0·02] levels than males. In multiple regression analysis, IGF‐1 was closely associated with logGH (estimate 139, SE 47, P = 0·005) and BMI (estimate 14·2, SE 4·8, P = 0·005). sK l was closely associated with logGH (estimate 3088, SE 652, P = 0·0001) and gender (estimate 2034, SE 612, P = 0·002), and to a lesser extent with BMI (estimate 174, SE 66, P = 0·01). Conclusions For a given GH status, sK l concentrations are higher and IGF‐1 concentrations are lower in women than in men. GH is the strongest predictor for both sK l and IGF‐1, but gender needs to be considered when using these parameters for monitoring acromegalic patients.