Premium
SFRP 5 correlates with obesity and metabolic syndrome and increases after weight loss in children
Author(s) -
Tan Xinrui,
Wang Xiaoli,
Chu Haiping,
Liu Honghong,
Yi Xiaoqing,
Xiao Yanfeng
Publication year - 2014
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12361
Subject(s) - medicine , metabolic syndrome , obesity , body mass index , endocrinology , waist , insulin resistance , adipokine , anthropometry , weight loss
Summary Objective Secreted frizzled‐related protein 5 ( SFRP 5) is a novel anti‐inflammatory adipokine, which has been shown as a mediator between obesity and its comorbidities. The aim of this study was to evaluate the associations of SFRP 5 with metabolic syndrome ( M et S ) and the effects of lifestyle interventions on circulating SFRP 5 levels in children. Design A cross‐sectional study was conducted among 111 obese children and 49 lean controls, and a lifestyle intervention was performed in a subgroup of 31 obese children for 6 months. Anthropometric parameters, clinical data and circulating SFRP 5 levels were measured at baseline and after lifestyle intervention. Results Secreted frizzled‐related protein 5 was significantly lower in obese children, especially in those with M et S , and negatively correlated with body mass index ( BMI ), waist circumference and homeostasis model assessment of insulin resistance. Independent of other well‐known risk factors, SFRP 5 was a significant predictor of M et S in children. In the longitudinal study, lifestyle intervention led to significant weight loss and higher SFRP 5 levels. Furthermore, changes in BMI significantly correlated with the rising magnitude of SFRP 5. Conclusions Serum SFRP 5 is regulated by weight status and seems to be correlated with metabolic disorders in children.