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Letrozole stimulation in endometrial preparation for cryopreserved–thawed embryo transfer in women with polycystic ovarian syndrome: A pilot study
Author(s) -
Hu YanJun,
Chen YueZhou,
Zhu YiMin,
Huang HeFeng
Publication year - 2014
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12280
Subject(s) - letrozole , embryo transfer , stimulation , in vitro fertilisation , medicine , aromatase inhibitor , polycystic ovary , endocrinology , pregnancy rate , ovarian hyperstimulation syndrome , gynecology , pregnancy , andrology , biology , tamoxifen , insulin , breast cancer , cancer , insulin resistance , genetics
Summary Objective To study the efficiency of letrozole, an aromatase inhibitor, in endometrial preparation for cryopreserved–thawed embryo transfer ( FET ) in women with polycystic ovarian syndrome ( PCOS ). Design Retrospective observational study. Patients One hundred and twenty patients with PCOS who met the inclusion criteria for the study. Measurements We assessed in vitro fertilization outcomes in one hundred and twenty patients with PCOS (148 cycles) who were prepared for and underwent FET between June 2011 and December 2012. Patients were prepared for FET using artificial hormone cycles induced with oestrogen and progesterone supplementation ( n = 76), letrozole stimulation ( n = 40) or hMG stimulation ( n = 32). Results There were no differences in demographic characteristics between the groups, except that the letrozole group had a higher incidence of embryo transfer failure in the past. The letrozole stimulation group had a significantly higher maximal endometrial thickness and significantly higher rates of clinical pregnancy per transfer, ongoing pregnancy per transfer and implantation, compared with the artificial and hMG stimulation groups. Differences in these parameters between the artificial and hMG stimulation groups were not significant. Conclusion Using letrozole stimulation in endometrial preparation for cryopreserved–thawed embryo transfer in patients with PCOS may be associated with better outcomes than using hormonal manipulation or hMG stimulation.