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Parathyroid hormone, vitamin D levels and urine albumin excretion in older persons: the 2011 Korea National Health and Nutrition Examination Survey ( KNHANES )
Author(s) -
Kim HyunWoo,
Park Hyunkyoung,
Cho Kyung Hwan,
Han Kyungdo,
Ko ByungJoon
Publication year - 2014
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12246
Subject(s) - national health and nutrition examination survey , medicine , quartile , parathyroid hormone , endocrinology , vitamin d and neurology , anthropometry , odds ratio , creatinine , urinary system , confidence interval , population , environmental health , calcium
Summary Objective Persistent elevation of urinary albumin excretion ( UAE ), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone ( PTH ) also increase cardiovascular disease risk. This study is intended to investigate the relationship between PTH , vitamin D levels and UAE . Methods We examined 2897 adults aged 50 and above, participating in the second year of the fifth Korea National Health and Nutrition Examination Survey ( KNHANES V‐2). Anthropometric and laboratory measurements were performed. Elevated UAE was defined as spot urinary albumin creatinine ratio equal or above 10. Results The proportion of elevated UAE (21·8%, 23·2%, 23·2%, 31·8%; P for trend = 0·002) rose with increasing quartiles of PTH . The odds ratio for elevated UAE in the highest quartile of PTH was 72% higher than the lowest quartile group. There was no relationship between vitamin D and elevated UAE . Conclusions Elevated PTH levels are associated with elevated UAE in Korean adults aged 50 and above. Additional studies are needed to clarify this relationship.