Premium
Random measurements of adiponectin and IL ‐6 may not be indicative of the 24‐h profile in critically ill patients
Author(s) -
Robinson Katherine,
Jones Mark,
Ordonez Jenny,
Grice Jeffrey,
Davidson Ben,
Prins John,
Venkatesh Bala
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12233
Subject(s) - adiponectin , medicine , critically ill , critical illness , prospective cohort study , endocrinology , obesity , insulin resistance
Summary Context The anti‐inflammatory role of adiponectin has prompted interest in a potential role in acute inflammatory conditions associated with critical illness. It is unclear whether a random adiponectin measurement adequately reflects the 24‐h profile in critically ill patients. Objective To assess the temporal profile of total and high molecular weight ( HMW ) adiponectin and interleukin‐6 ( IL ‐6) in 15 critically ill patients. Design A prospective, observational study. Setting Level II intensive care unit in a metropolitan hospital. Patients or Other Participants Fifteen critically ill patients expected to stay in the ICU for longer than 48 h were eligible for enrolment. Intervention(s) None. Main Outcome Measure(s) Serial, hourly measurements of total and HMW adiponectin and IL ‐6. Results Over a 24‐h period, total and HMW adiponectin display considerable within‐patient variability (coefficient of variation 34% and 87% respectively) and show no trend over time. Averaging 2 or 3 continuous measures reduced within‐patient variability of both total and HMW adiponectin by up to 50% compared to one measure. There was a negative correlation between serum glucose and adiponectin (total P = 0·016, HMW P = 0·039). No relationship existed between adiponectin and IL ‐6 (total P = 0·62, HMW P = 0·35). Conclusions Marked within‐patient, hourly variability in total and HMW adiponectin is evident in critically ill patients. A random measurement may not be reflective of the 24‐h profile in these patients. A negative correlation exists between adiponectin and blood glucose levels and a positive correlation between adiponectin and oxygen saturation. No clear relationship exists between adiponectin and IL ‐6.