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Maternal thyroid parameters, body mass index and subsequent weight gain during pregnancy in healthy euthyroid women
Author(s) -
Pop Victor J.,
Biondi Bernadette,
Wijnen Hennie A.,
Kuppens Simone M.,
LVader Huib
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12177
Subject(s) - weight gain , gestation , medicine , euthyroid , thyroid function , body mass index , pregnancy , thyroid , thyroid stimulating hormone , endocrinology , obstetrics , thyroid function tests , body weight , biology , genetics
Summary Context Obesity and too much weight gain during gestation have a negative effect on obstetric and neonatal outcomes. Objective To determine the relationship between thyroid hormone parameters, body mass index ( BMI ) and weight gain during gestation. Design Prospective follow‐up study of thyroid parameters and gestational weight gain. Setting Healthy pregnant women, included at first antenatal consultation. Patients Thyroid function ( TSH , FT 4 and TPO ‐Ab) was assessed at 12, 24 and 36 weeks’ gestation in 1035 D utch C aucasian women who delivered at ≥37 weeks. BMI ( WHO criteria) was assessed at eight weeks, and weight gain throughout gestation was also assessed using the US Institute of Medicine ( IOM ) criteria. Measurements Primary outcome measure: a possible relationship between maternal thyroid parameters and BMI at the first trimester. Secondary outcome measure: the relationship between thyroid parameters and weight gain throughout gestation. Results At 12 weeks’ gestation, BMI correlated with FT 4 ( r = −0·14, P < 0·001), but not with TSH ( r = 0·04, P = 0·89). 415 (40%) of the women met the IOM criteria for appropriate weight gain, 326 (32%) showed less weight gain and 294 (28%) gained too much weight. At all trimesters, the latter group of women showed higher median TSH and lower median FT 4 compared with those with normal weight gain. FT 4 at 24 weeks’ gestation (OR: 0·84, 95% CI : 0·77–0·91), younger age (OR: 0·97, 95% CI : 0·95–0·99) and primiparity (OR: 0·51, 95% CI : 0·38–0·68) were independently related to too much weight gain. Conclusions Maternal thyroid parameters are related to both prepregnancy BMI and weight gain throughout gestation.