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Serum FGF 21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status
Author(s) -
Lee Yenna,
Lim Soo,
Hong EunShil,
Kim Jung Hee,
Moon Min Kyung,
Chun Eun Ju,
Choi Sang Il,
Kim YoungBum,
Park Young Joo,
Park Kyong Soo,
Jang Hak C.,
Choi Sung Hee
Publication year - 2014
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12134
Subject(s) - medicine , endocrinology , coronary artery disease , diabetes mellitus , body mass index , obesity , insulin , fgf21 , metabolic syndrome , fibroblast growth factor , receptor
Summary Objective Fibroblast growth factor 21 ( FGF 21) is an emerging metabolic regulator associated with glucose and lipid metabolism. However, previous studies of FGF 21 have been largely confounded by obesity, and data are limited for advanced outcomes such as coronary artery disease ( CAD ) and ectopic fat accumulation. We investigated the associations between serum FGF 21 concentrations and glucose/lipid metabolism, CAD , and pericardial fat deposition in subjects strictly matched for obesity parameters. Design, Patients and Measurements We enrolled 189 patients who had undergone cardiac multidetector coronary computed tomography. We measured cardiometabolic parameters and serum FGF 21 levels within body mass index ( BMI )‐matched groups. Correlations and linear regressions were analysed among serum FGF 21 levels, pericardial fat volumes and cardiometabolic parameters. Serum FGF 21 concentrations were compared in patients with and without diabetes, metabolic syndrome ( MS ) or CAD . Results Serum FGF 21 concentrations were significantly higher in BMI ‐matched patients with MS (107·2 ± 83·6 vs 82·1 ± 67·4 ng/l without MS , P < 0·05), but not among those with diabetes (84·3 ± 56·4 vs 96·3 ± 98·9 ng/l without diabetes, P = 0·300) or CAD (89·6 ± 65·8 vs 84·2 ± 83·1 ng/l without CAD , P = 0·633). Serum FGF 21 concentrations correlated positively with triglycerides, low‐density lipoprotein–cholesterol, insulin, HOMA ‐ IR and pericardial fat volume. They showed an independent association with pericardial fat volume (β = 0·111 ± 0·053, P < 0·05). Conclusions Serum FGF 21 concentrations were significantly associated with lipid profiles, insulin resistance, pericardial fat volume and MS , independently of obesity, but not with overt CAD or diabetes.