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Circulating interleukin 6 and soluble forms of its receptors in relation to resting energy expenditure in women with anorexia nervosa
Author(s) -
KarczewskaKupczewska Monika,
Adamska Agnieszka,
Nikołajuk Agnieszka,
Otziomek Elżbieta,
Górska Maria,
Kowalska Irina,
Strączkowski Marek
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12118
Subject(s) - anorexia nervosa , endocrinology , medicine , receptor , anorexia , resting energy expenditure , energy expenditure , eating disorders , psychiatry
Context Anorexia nervosa ( AN ) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL‐6) may play a role in appetite, energy expenditure and body weight control. IL‐6 acts through binding with membrane receptor (IL‐6R) and activates glycoprotein 130 (gp130) signalling. Both IL‐6R and gp130 are present in the blood in the soluble forms ( sIL ‐6R and sgp130 respectively). sIL ‐6R sensitizes cells towards IL‐6, whereas sgp130 inhibits gp130 signalling. Objective To estimate circulating IL‐6/ sIL ‐6R/sgp130 system and its relationships with body weight and resting energy expenditure ( REE ) in AN women. Patients We examined 19 women with AN and 27 healthy normal‐weight female controls. Measurements Indirect calorimetry and the measurement of serum IL‐6, sIL ‐6R and sgp130 concentrations were performed in all the subjects. Results REE was decreased in AN women ( P < 0·001). Serum IL‐6 was higher in AN women in comparison with control group ( P = 0·005). Serum sIL ‐6R was lower ( P = 0·009) and serum sgp130 was higher ( P = 0·004) in AN women in comparison with controls. IL‐6 and sIL ‐6R were related to REE in the entire study population ( r = −0·54, P < 0·001 and r = 0·48, P = 0·001 respectively) and in AN group ( r = −0·54, P = 0·024 and r = 0·60, P = 0·011 respectively). Conclusions Increased IL ‐6 in AN seems to be compensated by the changes in sIL ‐6R and sgp130, which are directed towards inhibition of IL ‐6 action. The balance between these factors might play a role in the regulation of energy expenditure in AN .