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Sex‐dependent associations of genetic variants identified by GWAS with indices of adiposity and obesity risk in a C hinese children population
Author(s) -
Xi Bo,
Shen Yue,
Reilly Kathleen Heather,
Zhao Xiaoyuan,
Cheng Hong,
Hou Dongqing,
Wang Xingyu,
Mi Jie
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12091
Subject(s) - obesity , body mass index , waist , genome wide association study , single nucleotide polymorphism , snp , medicine , population , demography , genetic association , biology , endocrinology , genetics , genotype , gene , environmental health , sociology
Summary Objective Recent genome‐wide association studies have identified a few single nucleotide polymorphisms ( SNP s), which are associated with body mass index ( BMI )/obesity. This study aimed to examine the identified associations among a population of Chinese children. Research design and methods Five SNP s ( SEC 16B rs10913469, SH 2B1 rs4788102, PCSK 1 rs6235, KCTD 15 rs29941, BAT 2 rs2844479) were genotyped for a group of C hinese children ( N = 2849, age range 6–18 years). A total of 1230 obese cases and 1619 controls with normal weight were identified based on the C hinese age‐ and sex‐specific BMI references. Results Of five studied variants, only two ( SEC 16B rs10913469, SH 2B1 rs4788102) were nominally associated with indices of adiposity and obesity risk in girls and only SEC 16B rs10913469 in children at puberty ( p < 0·05), while no statistical associations was found for three other variants ( PCSK 1 rs6235, KCTD 15 rs29941, BAT 2 rs2844479). After false discovery rate ( FDR ) adjustment for multiple testing, none were statistically significant. Further analysis indicated that the genetic risk score ( GRS ) was associated with BMI , waist circumference and risk of obesity (defined by BMI ) in girls, even after FDR adjustment for multiple testing. However, there was no statistical association of GRS with indices of adiposity and risk of obesity in children at puberty after multiple comparison correction. Conclusions This study confirmed the synthetic effect of SNP s on the indices of adiposity and risk of obesity in Chinese girls, but failed to replicate the effect of five separate variants. We also did not found cumulative effect of SNP s in children at puberty.