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What is the best approach to the teenage patient presenting with nonclassical C ongenital adrenal hyperplasia: should we always treat with glucocorticoids?
Author(s) -
Matthews Deborah,
Cheetham Tim
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12065
Subject(s) - antiandrogens , congenital adrenal hyperplasia , medicine , glucocorticoid , endocrinology , androgen excess , androgen , pill , androgen suppression , hormone , antiandrogen , pharmacology , insulin resistance , polycystic ovary , insulin
Summary Patients with C ongenital adrenal hyperplasia due to partial deficiency in the enzyme 21‐hydroxlyase can present in childhood or adolescence with signs of adrenal androgen excess. Strategies to reduce the impact of androgen excess in females include cosmetic measures as well as antiandrogens and agents such as the combined oral contraceptive pill. Glucocorticoid may not be appropriate straightaway but can be introduced if other measures are ineffective or when pregnancy is planned.