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Impact of age, phenotype and cardio‐renal function on plasma C ‐type and B ‐type natriuretic peptide forms in an adult population
Author(s) -
Prickett T. C. R.,
Olney R. C.,
Cameron V. A.,
Ellis M. J.,
Richards A. M.,
Espiner E. A.
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12035
Subject(s) - medicine , endocrinology , natriuretic peptide , population , renal function , creatinine , context (archaeology) , brain natriuretic peptide , heart failure , biology , paleontology , environmental health
Summary Context In contrast to the cardiac hormones, atrial natriuretic peptide ( ANP ) and B ‐type natriuretic peptide ( BNP ), variations in plasma concentrations of C ‐type natriuretic peptide ( CNP ) in healthy adults are ill‐defined, limiting their clinical application. Objective Our objective was to define the effect of age, phenotype (gender, height, BMI ), and cardiac and renal function on plasma CNP s in an adults population without renal or cardiovascular disease. Design and setting This was a prospective cross‐sectional observational study of adult volunteers, aged 21–80 years, randomly selected from the electoral roll. Subjects and methods Plasma CNP and its associated aminoterminal propeptide ( NT pro CNP ) were measured in 258 subjects and related to age, gender, height and plasma creatinine. Subgroup analyses seeking associations with cardiac function (plasma BNP and NT pro BNP ) and bone turnover bone‐specific alkaline phosphatase (b ALP ) were also determined. Results Plasma concentrations of CNP s in men continued to decline from adolescent values to reach a nadir in the 5th decade after which values increased. Similar but less marked changes occurred in women. In both sexes, NT pro CNP was inversely and independently correlated with height. In contrast to B ‐type natriuretic peptides ( BNP s), NT pro CNP was higher in men, significantly related to creatinine and positively related to b ALP . Conclusions Gender‐ and age‐specific changes affect CNP s in adults. Inverse associations of NT pro CNP with adult height, positive correlation with creatinine – and in contrast to CNP – no association with BNP are further unique findings distinguishing NT pro CNP , which need to be considered in future studies.