Premium
Thigh muscle attenuation measured by computed tomography was associated with the risk of low bone density in community‐dwelling elderly population
Author(s) -
Kim Jung Hee,
Choi Sung Hee,
Lim Soo,
Lim Jae Young,
Kim Ki Woong,
Park Kyong Soo,
Shin Chan Soo,
Jang Hak Chul
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12016
Subject(s) - femoral neck , medicine , bone mineral , thigh , lean body mass , bone density , population , quantitative computed tomography , sarcopenia , skeletal muscle , endocrinology , osteoporosis , anatomy , environmental health , body weight
Summary Objectives Although muscle mass has been shown to be positively related with bone mineral density ( BMD ), there are only a few studies that investigated the association between muscle strength or muscle quality and BMD . We investigated the effects of muscle strength and muscle fat infiltration, as a measure of muscle quality, adjusted for muscle mass on femoral neck BMD in K orean elderly cohort. Methods We recruited 242 men and 231 women aged over 65 years who participated in the K orean L ongitudinal S tudy on H ealth and A geing. Leg muscle mass and femoral neck BMD were measured by dual‐energy X‐ray absorptiometry. Isokinetic strength of knee extensors was measured as a peak torque value by an isokinetic device. Computed tomography scan of the mid‐thigh measured the mean H ounsfield unit ( HU ) of the lean tissue. Low bone density was defined as femoral neck T ‐score ≤−2·0. Results Leg muscle mass, knee extensor strength and thigh muscle HU values were significantly positively correlated with femoral neck BMD in both men and women. However, muscle strength was not a significant determinant for the presence of low bone mass after adjusting for muscle mass in multiple logistic regression analyses. Notably, thigh muscle HU values were strong and independent determinant for the risk of low bone density. Conclusion Decreased thigh muscle HU values, a measure of fatty infiltration of muscle, were independently associated with increased risk of low bone density in the elderly population.