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Prevalence of metabolic syndrome in women with polycystic ovary syndrome
Author(s) -
Panidis Dimitrios,
Macut Djuro,
Tziomalos Konstantinos,
Papadakis Efstathios,
Mikhailidis Konstantinos,
Kandaraki Eleni A.,
Tsourdi Elena A.,
Tantanasis Theoharis,
Mavromatidis George,
Katsikis Ilias
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12008
Subject(s) - metabolic syndrome , polycystic ovary , medicine , national cholesterol education program , abdominal obesity , insulin resistance , body mass index , obesity , anthropometry , endocrinology , cohort , logistic regression , gynecology
Summary Objective The polycystic ovary syndrome ( PCOS ) and the metabolic syndrome ( M et S ) are common disorders that share many characteristics, particularly abdominal obesity and insulin resistance. Our objective was to compare the prevalence of M et S between a large cohort of patients with PCOS and body mass index ‐matched controls. Design Cross‐sectional study. Patients We studied 1223 patients with PCOS and 277 healthy women. Diagnosis of PCOS was based on the revised R otterdam criteria. Women with PCOS were divided into those who fulfilled both the R otterdam criteria and the diagnostic criteria of the 1990 N ational I nstitutes of H ealth definition of PCOS (group 1, n = 905) and into those with the additional phenotypes introduced by the R otterdam criteria (group 2, n = 318). Diagnosis of M et S was based on four different definitions. Measurements Anthropometric, metabolic, hormonal and ultrasonographic features of PCOS . Results The prevalence of metabolic syndrome ( M et S ) was higher in women with PCOS than in controls when the N ational C holesterol E ducation P rogram A dult T reatment P anel III definition of M et S was applied (15·8% and 10·1%, respectively; P = 0·021) but not with the three more recent M et S definitions. The prevalence of M et S was higher in group 1 than in controls regardless of the applied M et S definition. In contrast, the prevalence of M et S was similar in group 2 and in controls regardless of the applied M et S definition. In logistic regression analysis, PCOS did not predict the presence of M et S . Conclusions Polycystic ovary syndrome per se does not appear to increase the risk of M et S independent of abdominal obesity.