Double‐negative (DN) B cells: an under‐recognized effector memory B cell subset in autoimmunity | Zendy

Li Yuzi | Zendy; Li Zhanguo | Zendy; Hu Fanlei | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Double‐negative (DN) B cells: an under‐recognized effector memory B cell subset in autoimmunity

Author(s) -

Li Yuzi,

Li Zhanguo,

Hu Fanlei

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13615

Subject(s) - immunoglobulin d , b cell , immunology , autoimmunity , effector , biology , antibody , b 1 cell , naive b cell , pathogenesis , t cell , immune system , antigen presenting cell

Summary Human B cells could be divided into four classical subsets based on CD27 and immunoglobulin (Ig)D expression. Distinct from the other three well‐studied subsets, CD27 − IgD − B cells, also termed as double‐negative (DN) B cells, have long been neglected. However, in recent years emerging evidence shows that DN B cells are unique memory B cells with important functions. They are expanded in a variety of diseases, especially in autoimmune diseases, contributing to the disease pathogenesis. Here, we briefly review the studies on DN B cells, including their origins, characteristics, subsets and roles in diseases, to try to bring new insights into this under‐recognized B cell subset.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research