Citrullinated inter‐alpha‐trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration | Zendy

Osada A. | Zendy; Matsumoto I. | Zendy; Mikami N. | Zendy; Ohyama A. | Zendy; Kurata I. | Zendy; Kondo Y. | Zendy; Tsuboi H. | Zendy; Ishigami A. | Zendy; Sano Y. | Zendy; Arai T. | Zendy; Ise N. | Zendy; Sumida T. | Zendy

Open Access

Citrullinated inter‐alpha‐trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration

Author(s) -

Osada A.,

Matsumoto I.,

Mikami N.,

Ohyama A.,

Kurata I.,

Kondo Y.,

Tsuboi H.,

Ishigami A.,

Sano Y.,

Arai T.,

Ise N.,

Sumida T.

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13556

Subject(s) - rheumatoid arthritis , immunology , arthritis , antibody , blot , biomarker , antigen , chemistry , medicine , biochemistry , gene

In this study, we presented clear evidence of the increased expression of citrullinated inter‐alpha‐trypsin inhibitor heavy chain 4 (cit‐ITIH4) both in joints from peptide glucose‐6‐phosphate isomerase‐induced arthritis (pGIA) mice and rheumatoid arthritis patients. Neutrophils with PAD4 in joints might contribute to this citrullination, which was shown by decreases in ITIH4 citrullination upon depletion of neutrophils by anti‐Ly6G antibodies in pGIA mice. In addition, we demonstrated that the citrullination of ITIH4 enhanced the migration of human neutrophils, supporting an association between cit‐ITIH4 and the generation of arthritis.

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