The tellurium‐based immunomodulator, AS101 ameliorates adjuvant‐induced arthritis in rats
Author(s) -
Halpert G.,
Halperin Sheinfeld M.,
Monteran L.,
Sharif K.,
Volkov A.,
Nadler R.,
Schlesinger A.,
Barshak I.,
Kalechman Y.,
Blank M.,
Shoenfeld Y.,
Amital H.
Publication year - 2021
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/cei.13553
Subject(s) - medicine , arthritis , rheumatoid arthritis , proinflammatory cytokine , immune system , immunology , inflammation , adjuvant , synovial membrane , autoantibody , antibody
We report an anti‐rheumatic/inflammatory activity of the non‐toxic, tellurium‐based immunomodulatory compound AS101 in experimental RA by reducing disease progression, by blocking extravasation of inflammatory VLA4+ cells into the joint and by preservation of joint tissue architecture.
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