A hyperacute immune map of ischaemic stroke patients reveals alterations to circulating innate and adaptive cells | Zendy

Krishnan S. | Zendy; O’Boyle C. | Zendy; Smith C. J. | Zendy; Hulme S. | Zendy; Allan S. M. | Zendy; Grainger J. R. | Zendy; Lawrence C. B. | Zendy

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A hyperacute immune map of ischaemic stroke patients reveals alterations to circulating innate and adaptive cells

Author(s) -

Krishnan S.,

O’Boyle C.,

Smith C. J.,

Hulme S.,

Allan S. M.,

Grainger J. R.,

Lawrence C. B.

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13551

Subject(s) - immunology , immune system , immunophenotyping , acquired immune system , cd14 , innate immune system , biology , myeloid , haematopoiesis , stem cell , medicine , antigen , microbiology and biotechnology

Stroke affects millions of people across the globe and infections following a stroke often lead to death or disability in patients. Looking rapidly after a stroke in patients, we identify early alterations to the innate and adaptive cells in circulation. Our findings highlight novel changes to dendritic cells, monocytes, haematopoietic stem and progenitor cells, B and T cells to be further investigated as they could have implications the development of post‐stroke infection and poorer patient outcomes.

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