Th22 response induced by  Mycobacterium tuberculosis  strains is closely related to severity of pulmonary lesions and bacillary load in patients with multi‐drug‐resistant tuberculosis | Zendy

Imperiale B. R. | Zendy; García A. | Zendy; Minotti A. | Zendy; González Montaner P. | Zendy; Moracho L. | Zendy; Morcillo N. S. | Zendy; Palmero D. J. | Zendy; Sasiain M. del Carmen | Zendy; Barrera S. | Zendy

Open Access

Th22 response induced by Mycobacterium tuberculosis strains is closely related to severity of pulmonary lesions and bacillary load in patients with multi‐drug‐resistant tuberculosis

Author(s) -

Imperiale B. R.,

García A.,

Minotti A.,

González Montaner P.,

Moracho L.,

Morcillo N. S.,

Palmero D. J.,

Sasiain M. del Carmen,

Barrera S.

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13544

Subject(s) - tuberculosis , peripheral blood mononuclear cell , mycobacterium tuberculosis , sputum , ex vivo , immunology , cd8 , pathogenesis , medicine , flow cytometry , drug resistance , in vivo , immune system , biology , microbiology and biotechnology , in vitro , pathology , biochemistry

Systemic and in vitro Th22 response induced by M. tuberculosis strains was explored in TB patients. In MDR‐TB patients, Th22 response was dependent on the bacillary load and the severity of lung lesions. Thus, this response could be influencing the ability of MDR‐TB patients to control bacillary growth and tissue damage.

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