CD40L‐stimulated B cells for  ex‐vivo  expansion of polyspecific non‐human primate regulatory T cells for translational studies | Zendy

AlonsoGuallart P. | Zendy; Llore N. | Zendy; Lopes E. | Zendy; Kofman S.B. | Zendy; Ho S.H. | Zendy; Stern J. | Zendy; Pierre G. | Zendy; Bruestle K. | Zendy; Tang Q. | Zendy; Sykes M. | Zendy; Griesemer A. | Zendy

Open Access

CD40L‐stimulated B cells for ex‐vivo expansion of polyspecific non‐human primate regulatory T cells for translational studies

Author(s) -

AlonsoGuallart P.,

Llore N.,

Lopes E.,

Kofman S.B.,

Ho S.H.,

Stern J.,

Pierre G.,

Bruestle K.,

Tang Q.,

Sykes M.,

Griesemer A.

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13537

Subject(s) - immunology , foxp3 , biology , transplantation , t cell , major histocompatibility complex , ex vivo , cd40 , antigen , immune system , cytotoxic t cell , in vivo , in vitro , medicine , genetics , surgery

We developed an approach for the expansion of Mauritian cynomolgus macaque polyspecific regulatory T cells (Tregs) through the combination of MHC‐mismatched CD40L‐engineered B cells. Expanded Tregs expressed high levels of FoxP3 and Helios, a high percentage of TSDR demethylation, and strong suppression of naïve T cell responses in vitro . This approach has the potential to be translated to clinical studies for deceased‐donor transplants.

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