Identification of peripheral CD154 +  T cells and HLA‐DRB1 as biomarkers of acute cellular rejection in adult liver transplant recipients | Zendy

Boix F. | Zendy; Legaz I. | Zendy; Minhas A. | Zendy; Alfaro R. | Zendy; Jiménez–Coll V. | Zendy; Mrowiec A. | Zendy; Martínez–Banaclocha H. | Zendy; Galián J. A. | Zendy; Botella C. | Zendy; Moya–Quiles M. R. | Zendy; Sanchez–Bueno F. | Zendy; Robles R. | Zendy; Peña–Moral J. | Zendy; Ramirez P. | Zendy; Pons J. A. | Zendy; Minguela A. | Zendy; Muro M. | Zendy

Open Access

Identification of peripheral CD154 + T cells and HLA‐DRB1 as biomarkers of acute cellular rejection in adult liver transplant recipients

Author(s) -

Boix F.,

Legaz I.,

Minhas A.,

Alfaro R.,

Jiménez–Coll V.,

Mrowiec A.,

Martínez–Banaclocha H.,

Galián J. A.,

Botella C.,

Moya–Quiles M. R.,

Sanchez–Bueno F.,

Robles R.,

Peña–Moral J.,

Ramirez P.,

Pons J. A.,

Minguela A.,

Muro M.

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13533

Subject(s) - cd154 , cd8 , immunology , medicine , t cell , flow cytometry , antigen , cd40 , transplantation , human leukocyte antigen , liver transplantation , immune system , cytotoxic t cell , biology , biochemistry , in vitro

Mechanisms of acute cellular allograft rejection followed liver transplantation employs the activation, proliferation and differentiation of CD4 + CD154 + and CD8 + CD154 + T cells into effector cells triggered by direct allorecognition pathway, which is performed by both but is dominated by CD4 + T cells, and indirect allorecognition pathway virtually restricted to CD8 + T cells·

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