Open AccessIncreased expression of CXCL2 in ACPA‐positive rheumatoid arthritis and its role in osteoclastogenesis
Author(s) -
Wang X.,
Sun L.,
He N.,
An Z.,
Yu R.,
Li C.,
Li Y.,
Liu X.,
Fang X.,
Zhao J.
Publication year - 2021
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/cei.13527
Subject(s) - cxcl2 , immunology , medicine , transcriptome , chemokine , biology , gene expression , gene , chemokine receptor , inflammation , genetics
CXCL2 was highly expressed in ACPA + RA than in ACPA − RA. CXCL2 promoted osteoclastogenesis and was related to bone erosion in RA, which suggest that the blockade of CXCL2 might be a novel strategy for the treatment of RA.
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