Association of the polymorphism of the Toll‐like receptor (TLR)‐3 and TLR‐9 genes with hepatitis C virus‐specific cell‐mediated immunity outcomes among Egyptian health‐care workers | Zendy

Abdelwahab S. F. | Zendy; Hamdy S. | Zendy; Osman A. M. | Zendy; Zakaria Z. A. | Zendy; Galal I. | Zendy; Sobhy M. | Zendy; Hashem M. | Zendy; Allam W. R. | Zendy; AbdelSamiee M. | Zendy; Rewisha E. | Zendy; Waked I. | Zendy

Open Access

Association of the polymorphism of the Toll‐like receptor (TLR)‐3 and TLR‐9 genes with hepatitis C virus‐specific cell‐mediated immunity outcomes among Egyptian health‐care workers

Author(s) -

Abdelwahab S. F.,

Hamdy S.,

Osman A. M.,

Zakaria Z. A.,

Galal I.,

Sobhy M.,

Hashem M.,

Allam W. R.,

AbdelSamiee M.,

Rewisha E.,

Waked I.

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13514

Subject(s) - genotype , immunology , hepatitis c virus , single nucleotide polymorphism , virology , elispot , biology , toll like receptor , tlr9 , innate immune system , virus , immune system , gene , t cell , genetics , gene expression , dna methylation

We previously reported that TLR3.rs3775290 ‘CC’ genotype was associated with HCV chronicity, while TLR9 gene played no role in this infection. Herein, we show a significant association between the outcome of the HCV‐specific cell‐mediated immune (CMI) response and TLR9.rs5743836 genotype among the total responding subjects with different HCV states (p=0.005) and among the chronic HCV patients (p=0.044). We conclude that TLR9.rs5743836 SNP; but not TLR3.rs3775290 or TLR9.rs352140 genotypes; could predict the outcome of HCV‐specific CMI responses among HCV genotype‐4‐infected Egyptians.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research