Mycoplasma pneumoniae  lipids license TLR‐4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response | Zendy

Luo H. | Zendy; He J. | Zendy; Qin L. | Zendy; Chen Y. | Zendy; Chen L. | Zendy; Li R. | Zendy; Zeng Y. | Zendy; Zhu C. | Zendy; You X. | Zendy; Wu Y. | Zendy

Open Access

Mycoplasma pneumoniae lipids license TLR‐4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response

Author(s) -

Luo H.,

He J.,

Qin L.,

Chen Y.,

Chen L.,

Li R.,

Zeng Y.,

Zhu C.,

You X.,

Wu Y.

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13510

Subject(s) - proinflammatory cytokine , inflammasome , mycoplasma pneumoniae , biology , immunology , autophagy , inflammation , tlr2 , tlr4 , microbiology and biotechnology , medicine , pneumonia , apoptosis , biochemistry

TLR4 is usually not assumed to be involved in Mycoplasma recognition. In this study we showed that the Mycoplasma pneumoniae ‐derived lipids did interact with TLR4 which subsequently initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF‐κB signalling cascade, ultimately promoting proinflammatory cytokines production in macrophages.

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