Identification of a unique anti‐Ro60 subset with restricted serological and molecular profiles | Zendy

Lee A. Y. S. | Zendy; Beroukas D. | Zendy; Brown L. | Zendy; Lucchesi C. | Zendy; Kaur A. | Zendy; Gyedu L. | Zendy; Hughes N. | Zendy; Ng Y. H. | Zendy; Saran O. | Zendy; Gordon T. P. | Zendy; Wang J. J. | Zendy

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Identification of a unique anti‐Ro60 subset with restricted serological and molecular profiles

Author(s) -

Lee A. Y. S.,

Beroukas D.,

Brown L.,

Lucchesi C.,

Kaur A.,

Gyedu L.,

Hughes N.,

Ng Y. H.,

Saran O.,

Gordon T. P.,

Wang J. J.

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13508

Subject(s) - serology , autoantibody , immunology , isotype , concordance , medicine , immunopathology , precipitin , antibody , monoclonal antibody

Anti‐Ro60 is one of the most important and common autoantibodies found in systemic autoimmune diseases. Using a range of traditional diagnostic laboratory assays and innovative mass spectrometry, authors dissect low from high expression of anti‐Ro60 and the clinical implications of this. Low expression of anti‐Ro60 was found to be a serologically and molecularly distinct entity that has important clinical relevance.

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