Food allergy promotes a Th2/Th17 response that drives house dust mite‐induced allergic airway inflammation in humanized mice | Zendy

Wang B. | Zendy; Hu J. | Zendy; Liu Y. | Zendy; Liu Q. | Zendy; Li D. | Zendy

Open Access

Food allergy promotes a Th2/Th17 response that drives house dust mite‐induced allergic airway inflammation in humanized mice

Author(s) -

Wang B.,

Hu J.,

Liu Y.,

Liu Q.,

Li D.

Publication year - 2020

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13504

Subject(s) - immunology , house dust mite , allergy , medicine , immunoglobulin e , peripheral blood mononuclear cell , sensitization , peanut allergy , humanized mouse , allergic inflammation , asthma , food allergy , allergen , inflammation , immune system , antibody , biology , biochemistry , in vitro

A preceding peanut sensitization amplifies allergic asthma accompanied by enhanced Th2/Th17 response in PBMC‐engrafted humanized mice. This murine model could be instrumental to further elucidate the mechanisms of interplay between different primary sensitizations, which is also suitable for investigating existing drugs, novel pharmacologic and immunologic intervention for treatment of allergic diseases.

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