The alternative complement pathway in ANCA‐associated vasculitis: further evidence and a meta‐analysis | Zendy

Moiseev S. | Zendy; Lee J. M. | Zendy; Zykova A. | Zendy; Bulanov N. | Zendy; Novikov P. | Zendy; Gitel E. | Zendy; Bulanova M. | Zendy; Safonova E. | Zendy; Shin J. I. | Zendy; Kronbichler A. | Zendy; Jayne D. R. W. | Zendy

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The alternative complement pathway in ANCA‐associated vasculitis: further evidence and a meta‐analysis

Author(s) -

Moiseev S.,

Lee J. M.,

Zykova A.,

Bulanov N.,

Novikov P.,

Gitel E.,

Bulanova M.,

Safonova E.,

Shin J. I.,

Kronbichler A.,

Jayne D. R. W.

Publication year - 2020

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13498

Subject(s) - properdin , complement factor b , alternative complement pathway , complement system , immunology , microscopic polyangiitis , granulomatosis with polyangiitis , medicine , vasculitis , pathogenesis , immunosuppression , factor h , meta analysis , complement membrane attack complex , disease , antibody

Alternative pathway complement activation in ANCA‐associated vasculitis is a key feature in the pathogenesis. Our findings reinforce the finding that complement C5a and C3a are regulated during phases of disease activity. Meta‐analysis revealed significant changes in MAC, C5a, factor B, and borderline changes in C3a.

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