Activated inducible co‐stimulator‐positive programmed cell death 1‐positive follicular helper T cells indicate disease activity and severity in ulcerative colitis patients | Zendy

Long Y. | Zendy; Zhao X. | Zendy; Liu Chang | Zendy; Xia C. | Zendy; Liu Chen | Zendy

Open Access

Activated inducible co‐stimulator‐positive programmed cell death 1‐positive follicular helper T cells indicate disease activity and severity in ulcerative colitis patients

Author(s) -

Long Y.,

Zhao X.,

Liu Chang,

Xia C.,

Liu Chen

Publication year - 2020

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13485

Subject(s) - ulcerative colitis , flow cytometry , immunology , medicine , follicular phase , antibody , receiver operating characteristic , disease

Our study suggests that the activated ICOS + PD‐1 + Tfh cells are involved in the disease activity of UC, and the underlying mechanisms may be through promoting the differentiation of functional B cells caused by elevated serum IL‐4 and IL‐21. Furthermore, activated ICOS + PD‐1 + Tfh cells, together with PD‐1 + Tfh cells or not, are reliable biomarkers for UC disease activity monitoring.

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