The suppressive effect on CD4 T cell alloresponse against endothelial HLA‐DR via PD‐L1 induced by anti‐A/B ligation | Zendy

Iwasaki K. | Zendy; Hamana H. | Zendy; Kishi H. | Zendy; Yamamoto T. | Zendy; Hiramitsu T. | Zendy; Okad M. | Zendy; Tomosugi T. | Zendy; Takeda A. | Zendy; Narumi S. | Zendy; Watarai Y. | Zendy; Miwa Y. | Zendy; Okumura M. | Zendy; Matsuoka Y. | Zendy; Horimi K. | Zendy; Muraguchi A. | Zendy; Kobayashi T. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The suppressive effect on CD4 T cell alloresponse against endothelial HLA‐DR via PD‐L1 induced by anti‐A/B ligation

Author(s) -

Iwasaki K.,

Hamana H.,

Kishi H.,

Yamamoto T.,

Hiramitsu T.,

Okad M.,

Tomosugi T.,

Takeda A.,

Narumi S.,

Watarai Y.,

Miwa Y.,

Okumura M.,

Matsuoka Y.,

Horimi K.,

Muraguchi A.,

Kobayashi T.

Publication year - 2020

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13482

Subject(s) - immunology , antibody , t cell , biology , il 2 receptor , antigen , human leukocyte antigen , immune system

Alloreactive and proliferating CD4 T‐cells recognizing allogeneic/donor HLA‐DR molecules on endothelial cells were attenuated in the presence of anti‐A/B antibodies. Anti‐A/B antibodies ligation on endothelial cells increased PD‐L1 expression. Amplified expression of transcript encoding PD‐L1 was observed in biopsy samples from ABO‐I renal transplants.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research