Leonurus sibiricus  root extracts decrease airway remodeling markers expression in fibroblasts | Zendy

Wieczfinska J. | Zendy; Sitarek P. | Zendy; Kowalczyk T. | Zendy; Pawliczak R. | Zendy

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Leonurus sibiricus root extracts decrease airway remodeling markers expression in fibroblasts

Author(s) -

Wieczfinska J.,

Sitarek P.,

Kowalczyk T.,

Pawliczak R.

Publication year - 2020

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13481

Subject(s) - fibroblast , transforming growth factor , biology , arginase , matrix metalloproteinase , chemistry , microbiology and biotechnology , immunology , biochemistry , in vitro , amino acid , arginine

Airway remodeling is a complex process, and controlling it appears to be a key for halting the progression of asthma and other obstructive lung diseases. The aim of this study was to evaluate the anti‐remodeling properties of extracts from transformed and transgenic L. sibiricus roots with overexpression of AtPAP1 transcriptional factor. Our study shows for the first time that transformed AtPAP1 TR extract from L. sibiricus root may affect the remodeling process.

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