Generation of a novel CD30 +  B cell subset producing GM‐CSF and its possible link to the pathogenesis of systemic sclerosis | Zendy

Higashioka K. | Zendy; Kikushige Y. | Zendy; Ayano M. | Zendy; Kimoto Y. | Zendy; Mitoma H. | Zendy; Kikukawa M. | Zendy; Akahoshi M. | Zendy; Arinobu Y. | Zendy; Horiuchi T. | Zendy; Akashi K. | Zendy; Niiro H. | Zendy

Open Access

Generation of a novel CD30 + B cell subset producing GM‐CSF and its possible link to the pathogenesis of systemic sclerosis

Author(s) -

Higashioka K.,

Kikushige Y.,

Ayano M.,

Kimoto Y.,

Mitoma H.,

Kikukawa M.,

Akahoshi M.,

Arinobu Y.,

Horiuchi T.,

Akashi K.,

Niiro H.

Publication year - 2020

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13477

Subject(s) - immunology , cytokine , biology , cd40 , population , cancer research , medicine , cytotoxic t cell , biochemistry , environmental health , in vitro

Systemic sclerosis (SSc) is a Th2‐associated fibroinflammatory autoimmune disease, in which B cells are suggested to exert antibody‐independent functions. We found that CD30+GM‐CSF‐producing B cells (GM‐Beffs) were generated from memory B cells by Th2 cytokines along with TGF‐β and induced differentiation to monocyte‐derived dendritic cells. CD30+GM‐Beffs were increased in SSc patients with the diffuse type and concomitant ILD, suggesting their pivotal role in disease pathogenesis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research