The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and/or cytokines | Zendy

Hahn S. | Zendy; Hasler P. | Zendy; Vokalova L. | Zendy; van Breda S. V. | Zendy; Lapaire O. | Zendy; Than N. G. | Zendy; Hoesli I. | Zendy; Rossi S. W. | Zendy

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The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and/or cytokines

Author(s) -

Hahn S.,

Hasler P.,

Vokalova L.,

van Breda S. V.,

Lapaire O.,

Than N. G.,

Hoesli I.,

Rossi S. W.

Publication year - 2019

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13278

Subject(s) - hormone , pregnancy , immunology , innate immune system , immune system , biology , female reproductive tract , menstrual cycle , inflammation , medicine , uterus , endocrinology , genetics

Summary Neutrophils are often exclusively considered as a first‐line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over‐activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrating this regulation are cyclical steroid sex hormones present during the menstrual cycle and pregnancy. This review describes the role of sex hormones in regulating directly or indirectly the functionality of neutrophils, the role of neutrophils during fertilization and pregnancy and in controlling viral, fungal and bacterial infection. This review also discusses the consequence of overt neutrophil activation in pregnancy pathologies.

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