FoxP3 + CXCR5 + CD4 +  T cell frequencies are increased in peripheral blood of patients with primary Sjögren’s syndrome | Zendy

Ivanchenko M. | Zendy; Aqrawi L.A. | Zendy; Björk A. | Zendy; WahrenHerlenius M. | Zendy; Chemin K. | Zendy

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FoxP3 + CXCR5 + CD4 + T cell frequencies are increased in peripheral blood of patients with primary Sjögren’s syndrome

Author(s) -

Ivanchenko M.,

Aqrawi L.A.,

Björk A.,

WahrenHerlenius M.,

Chemin K.

Publication year - 2019

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13244

Subject(s) - peripheral blood , immunology , medicine , foxp3 , peripheral , cd4 t cell , cxcr5 , t cell , autoimmunity , sjögren syndrome , immunopathology , systemic disease , b cell , antibody , immune system , germinal center

We recently explored the expression of CXCR5 on T and B cells from peripheral blood of patients with primary Sjögren’s syndrome (SS). Here we investigated the frequency of CD25 + FoxP3 + CD4 + regulatory T cells (T regs ) among CXCR5 + CD4 + follicular cells in the same cohort of patients. We confirm that the frequency of T regs among follicular T cells is increased in SS patients and also provide novel data showing an increased frequency of PD‐1 expressing cells among CXCR5 + FoxP3 + CD4 + T cells.

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