Serum exosomes of chronic gastritis patients infected with  Helicobacter pylori  mediate IL‐1α expression via IL‐6 trans‐signalling in gastric epithelial cells | Zendy

Chen Y. | Zendy; Wang X. | Zendy; Yu Y. | Zendy; Xiao Y. | Zendy; Huang J. | Zendy; Yao Z. | Zendy; Chen X. | Zendy; Zhou T. | Zendy; Li P. | Zendy; Xu C. | Zendy

Open Access

Serum exosomes of chronic gastritis patients infected with Helicobacter pylori mediate IL‐1α expression via IL‐6 trans‐signalling in gastric epithelial cells

Author(s) -

Chen Y.,

Wang X.,

Yu Y.,

Xiao Y.,

Huang J.,

Yao Z.,

Chen X.,

Zhou T.,

Li P.,

Xu C.

Publication year - 2018

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13200

Subject(s) - microvesicles , helicobacter pylori , secretion , proinflammatory cytokine , gastritis , immunology , microrna , exosome , biology , immune system , chronic gastritis , inflammation , medicine , endocrinology , gene , biochemistry

Summary Emerging evidence has linked the exosomes to many immunological disorders, including infectious diseases. However, knowledge regarding the role of exosomes in Helicobacter pylori infection is limited. Here, we show that serum exosomes from chronic gastritis patients with H. pylori infection (Hp exosomes) stimulate the expression of the soluble interleukin (IL)‐6 receptor (sIL‐6R), which is involved in IL‐6 trans‐signalling in gastric epithelial cells. Interestingly, sIL‐6R up‐regulates expression of the proinflammatory cytokine IL‐1α, and the neutralization of sIL‐6R suppresses IL‐1α secretion. Thus, Hp exosomes regulate IL‐1α expression via sIL‐6R‐mediated IL‐6 trans‐signaling. Altogether, this study reveals a novel perspective in which exosomes play a vital role in immunological mechanisms during H. pylori infection.

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