Regulatory T cells: tolerance induction in solid organ transplantation | Zendy

Vaikunthanathan T. | Zendy; Safinia N. | Zendy; Boardman D. | Zendy; Lechler R. I. | Zendy; Lombardi G. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Regulatory T cells: tolerance induction in solid organ transplantation

Author(s) -

Vaikunthanathan T.,

Safinia N.,

Boardman D.,

Lechler R. I.,

Lombardi G.

Publication year - 2017

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.12978

Subject(s) - transplantation , immunotherapy , immunology , organ transplantation , clinical trial , medicine , cell therapy , biology , cell , immune system , pathology , genetics

Summary The concept of regulatory T cell (T reg ) therapy in transplantation is now a reality. Significant advances in science and technology have enabled us to isolate human T regs , expand them to clinically relevant numbers and infuse them into human transplant recipients. With several Phase I/II trials under way investigating T reg safety and efficacy it is now more crucial than ever to understand their complex biology. However, our journey is by no means complete; results from these trials will undoubtedly provoke both further knowledge and enquiry which, alongside evolving science, will continue to drive the optimization of T reg therapy in the pursuit of transplantation tolerance. In this review we will summarize current knowledge of T reg biology, explore novel technologies in the setting of T reg immunotherapy and address key prerequisites surrounding the clinical application of T regs in transplantation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research