Open AccessTransplantation tolerance: the big picture. Where do we stand, where should we go?
Author(s) -
Waldmann H.
Publication year - 2017
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/cei.12933
Subject(s) - immunosuppression , transplantation , exploit , immune tolerance , immunology , immune system , medicine , biology , intensive care medicine , computer science , surgery , computer security
Summary A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance in order to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, to evolve a three‐stage tolerance‐inducing strategy for transplanted tissues.
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