Ageing and obesity similarly impair antibody responses | Zendy

Frasca D. | Zendy; Diaz A. | Zendy; Romero M. | Zendy; Blomberg B. B. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Ageing and obesity similarly impair antibody responses

Author(s) -

Frasca D.,

Diaz A.,

Romero M.,

Blomberg B. B.

Publication year - 2017

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.12824

Subject(s) - ageing , inflammation , immune system , immunology , obesity , medicine , systemic inflammation , immunosenescence

Summary Ageing is characterized by increased low‐grade chronic inflammation, which is a significant risk factor for morbidity and mortality of elderly individuals. Similar to ageing, obesity is considered to be an inflammatory predisposition associated with chronic activation of immune cells and consequent local and systemic inflammation. Both ageing and obesity are characterized by reduced innate and adaptive immune responses. This review focuses on B cells, how they may contribute, at least locally, to low‐grade chronic inflammation in ageing and obesity and on the mechanisms involved.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research