RNA binding proteins as regulators of immune cell biology | Zendy

Newman R. | Zendy; McHugh J. | Zendy; Turner M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

RNA binding proteins as regulators of immune cell biology

Author(s) -

Newman R.,

McHugh J.,

Turner M.

Publication year - 2016

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.12684

Subject(s) - biology , rna binding protein , polyadenylation , alternative splicing , immune system , rna splicing , rna , translation (biology) , gene expression , microbiology and biotechnology , regulation of gene expression , tristetraprolin , gene , genetics , immunology , gene isoform , messenger rna

Summary Sequence‐specific RNA binding proteins (RBP) are important regulators of the immune response. RBP modulate gene expression by regulating splicing, polyadenylation, localization, translation and decay of target mRNAs. Increasing evidence suggests that RBP play critical roles in the development, activation and function of lymphocyte populations in the immune system. This review will discuss the post‐transcriptional regulation of gene expression by RBP during lymphocyte development, with particular focus on the Tristetraprolin family of RBP.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research