Single nucleotide polymorphisms of  T oll‐like receptors and susceptibility to infectious diseases | Zendy

Skevaki C. | Zendy; Pararas M. | Zendy; Kostelidou K. | Zendy; Tsakris A. | Zendy; Routsias J. G. | Zendy

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Single nucleotide polymorphisms of T oll‐like receptors and susceptibility to infectious diseases

Author(s) -

Skevaki C.,

Pararas M.,

Kostelidou K.,

Tsakris A.,

Routsias J. G.

Publication year - 2015

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.12578

Subject(s) - biology , immunology , single nucleotide polymorphism , innate immune system , pattern recognition receptor , immunity , receptor , acquired immune system , proinflammatory cytokine , toll like receptor , infectious disease (medical specialty) , genetics , disease , immune system , gene , inflammation , medicine , genotype , pathology

Summary T oll‐like receptors ( TLRs ) are the best‐studied family of pattern‐recognition receptors ( PRRs ), whose task is to rapidly recognize evolutionarily conserved structures on the invading microorganisms. Through binding to these patterns, TLRs trigger a number of proinflammatory and anti‐microbial responses, playing a key role in the first line of defence against the pathogens also promoting adaptive immunity responses. Growing amounts of data suggest that single nucleotide polymorphisms ( SNPs ) on the various human TLR proteins are associated with altered susceptibility to infection. This review summarizes the role of TLRs in innate immunity, their ligands and signalling and focuses on the TLR SNPs which have been linked to infectious disease susceptibility.

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