Defective natural killer cell anti‐viral capacity in paediatric  HBV  infection | Zendy

Heiberg I. L. | Zendy; Pallett L. J. | Zendy; Winther T. N. | Zendy; Høgh B. | Zendy; Maini M. K. | Zendy; Peppa D. | Zendy

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Defective natural killer cell anti‐viral capacity in paediatric HBV infection

Author(s) -

Heiberg I. L.,

Pallett L. J.,

Winther T. N.,

Høgh B.,

Maini M. K.,

Peppa D.

Publication year - 2015

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.12470

Subject(s) - immunology , biology , immune system , hepatitis b virus , interferon , virology , cytolysis , effector , natural killer cell , virus , cytotoxic t cell , in vitro , biochemistry

Summary N atural killer ( NK ) cells exhibit dysregulated effector function in adult chronic hepatitis B virus ( HBV ) infection ( CHB ), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross‐sectional evaluation of NK cell frequency, phenotype and function in HBV ‐infected children relative to uninfected children. We observed a selective defect in NK cell interferon ( IFN )‐γ production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NK p30 on NK cells suggests a role of impaired NK ‐dendritic cell ( DC ) cellular interactions as a potential mechanism leading to reduced IFN ‐γ production. The finding that NK cells are already defective in paediatric CHB , albeit less extensively than in adult CHB , has potential implications for the timing of anti‐viral therapy aiming to restore immune control.

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