Dengue virus‐infected human dendritic cells reveal hierarchies of naturally expressed novel  NS 3  CD 8  T  cell epitopes | Zendy

Piazza P. | Zendy; Campbell D. | Zendy; Marques E. | Zendy; Hildebrand W. H. | Zendy; Buchli R. | Zendy; Mailliard R. | Zendy; Rinaldo C. R. | Zendy

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Dengue virus‐infected human dendritic cells reveal hierarchies of naturally expressed novel NS 3 CD 8 T cell epitopes

Author(s) -

Piazza P.,

Campbell D.,

Marques E.,

Hildebrand W. H.,

Buchli R.,

Mailliard R.,

Rinaldo C. R.

Publication year - 2014

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.12373

Subject(s) - epitope , virology , dengue virus , biology , ns3 , cd8 , antigen , dengue fever , serotype , virus , immunology , hepatitis c virus

Summary Detailed knowledge of dengue virus ( DENV ) cell‐mediated immunity is limited. In this study we characterize CD 8 + T lymphocytes recognizing three novel and two known non‐structural protein 3 peptide epitopes in DENV ‐infected dendritic cells. Three epitopes displayed high conservation (75–100%), compared to the others (0–50%). A hierarchy ranking based on magnitude and polyfunctionality of the antigen‐specific response showed that dominant epitopes were both highly conserved and cross‐reactive against multiple DENV serotypes. These results are relevant to DENV pathogenesis and vaccine design.

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