Cellular immune responses in multiple sclerosis patients treated with interferon‐beta | Zendy

Bustamante M. F. | Zendy; Rio J. | Zendy; Castro Z. | Zendy; Sánchez A. | Zendy; Montalban X. | Zendy; Comabella M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cellular immune responses in multiple sclerosis patients treated with interferon‐beta

Author(s) -

Bustamante M. F.,

Rio J.,

Castro Z.,

Sánchez A.,

Montalban X.,

Comabella M.

Publication year - 2013

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.12016

Subject(s) - peripheral blood mononuclear cell , multiple sclerosis , immune system , immunology , cytokine , medicine , interferon , interferon gamma , interleukin 2 , cellular immunity , interleukin , biology , in vitro , biochemistry

Summary We investigated cellular immune responses at baseline in peripheral blood mononuclear cells ( PBMC ) of patients with multiple sclerosis ( MS ) treated with interferon ( IFN)‐ β and classified into responders and non‐responders according to clinical response criteria. Levels for IFN ‐γ, interleukin ( IL) ‐17 A , IL ‐17 F , IL ‐10 and IL ‐4 were determined in activated PBMC of 10 responders, 10 non‐responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non‐responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN‐ β responders and non‐responders.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research