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Clinical characteristics and disease burden in prurigo nodularis
Author(s) -
Aggarwal P.,
Choi J.,
Sutaria N.,
Roh Y. S.,
Wongvibulsin S.,
Williams K. A.,
Huang A. H.,
Boozalis E.,
Le T.,
Chavda R.,
Gabriel S.,
Kwatra S. G.
Publication year - 2021
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.14722
Subject(s) - prurigo nodularis , medicine , dermatology life quality index , quality of life (healthcare) , pittsburgh sleep quality index , depression (economics) , atopic dermatitis , anxiety , dermatology , disease , physical therapy , young adult , sleep quality , psychiatry , macroeconomics , economics , cognition , nursing
Summary Background Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intense pruritus, but information on patient experience and impact on quality of life (QoL) remains understudied. Aim To characterize disease characteristics and QoL in a global sample of patients with PN. Methods An anonymous survey was distributed via patient support groups for PN. Results In total, 231 members responded to the survey. The majority of respondents reported itch localized both to nodules and to intervening skin (67.0%). Associated symptoms included prickling, pain, stinging and burning. The extensor lower legs (69% right, 67.3% left) and flexor forearms (66.1% right, 62% left) were the most common sites of itch. Participants reported frequent healthcare utilization, with 36.3% visiting a doctor ≥ 10 times in the past year. Physician‐diagnosed anxiety (45.4%), depression (16.4%) and the atopic triad (18.7%) were commonly reported. Patients with PN had mean scores of 16.4, 11.6 and 16.8 on the Dermatology Life Quality Index, Pittsburgh Sleep Quality Index and 5‐Dimensions Itch, respectively. Conclusions Severe pruritus with accompanying pain, stinging and burning is characteristic of PN, with the majority of patients experiencing itch in both nodular and interlesional skin. Patients further report decreased QoL scores and impaired sleep. Patient experiences should guide future management of PN.