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Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study
Author(s) -
Elman S. A.,
Joyce C.,
Costenbader K. H.,
Merola J. F.
Publication year - 2020
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.14014
Subject(s) - medicine , discoid lupus erythematosus , cohort , retrospective cohort study , systemic lupus erythematosus , lupus erythematosus , cohort study , dermatology , immunology , disease , antibody
Summary Determining the risk of progression to systemic lupus erythematosus (SLE) among patients diagnosed with discoid lupus erythematosus (DLE), and the time frame of this risk, are important clinical questions. Past reports have demonstrated a wide time frame of progression from DLE to SLE, with mean time to progression of approximately 8 years. Using data obtained from an academic lupus centre, we identified 32 patients who progressed from DLE to SLE. In our cohort, we found that the median time to progression from DLE to SLE was 453 days, much sooner than previously reported. We believe this information can help inform clinicians on monitoring visit intervals and how best to counsel patients on SLE progression.