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Association of interleukin‐6 gene promoter polymorphism with acne vulgaris and its severity
Author(s) -
Ragab M.,
Hassan E. M.,
Elneily D.,
Fathallah N.
Publication year - 2019
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13864
Subject(s) - acne , genotype , allele , medicine , gene polymorphism , interleukin , promoter , pathogenesis , gastroenterology , polymorphism (computer science) , immunology , gene , biology , genetics , dermatology , gene expression , cytokine
Summary Background Acne vulgaris ( AV ) is an inflammatory disorder with a possible genetic background. Different cytokines and mediators are involved in its pathogenesis. Aim Our aim was to investigate the interleukin (IL)‐6 572 polymorphism in patients with AV and its relation to patient sex and acne severity. Methods In total, 30 patients with acne and 20 healthy controls ( HC s) were enrolled. The Global Acne Grading System was used to assess acne severity. The IL ‐6 572 gene promoter polymorphism was assessed using the PCR –restriction fragment length polymorphism method. Results There was a significantly higher association of IL ‐6 572 variants genotypes in patients with acne (93%) compared with the HC group (45%) ( P < 0.001), with a higher incidence of the IL ‐6 572 CC polymorphism in patients with acne. A significant difference ( P < 0.001) between C and G alleles in patients vs. HC s was detected. There were no significant associations between the IL ‐6 572 variant genotypes and either patient sex or AV severity. Conclusion IL ‐6 gene promoter polymorphism might have a role in AV susceptibility but it is not related to AV severity.