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Sporadic pemphigus foliaceus and class II human leucocyte antigen allele associations in the white British and Indo‐Asian populations in the UK
Author(s) -
Saha M.,
Harman K.,
Mortimer N. J.,
Binda V.,
Black M. M.,
Kondeatis E.,
Vaughan R.,
Groves R. W.
Publication year - 2019
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13774
Subject(s) - allele , pemphigus foliaceus , human leukocyte antigen , immunology , allele frequency , genetic predisposition , biology , medicine , antigen , genetics , disease , gene , antibody , autoantibody
Summary Background Pemphigus foliaceus ( PF ) has both genetic and environmental susceptibility factors. Current data on human leucocyte antigen ( HLA ) in patients with sporadic PF are limited. Aim To better define the distribution of HLA alleles in patients with PF in the UK . Methods We recruited 36 patients [26 of white British ( WB ) descent, 10 of Indo‐Asian (IA) descent] with PF who were living in the UK and 159 ethnically matched normal controls, and analysed their class II HLA DRB 1 and DQB 1 allele distribution. Results There was an increased frequency of DRB 1*1404 in association with DQB 1*0503 in IA patients with PF . The DRB 1*04 allele group as a whole had an increased frequency ( P < 0.001) in the WB patient group compared with controls. The alleles contributing to this significance were DRB 1*0401 ( P = 0.03) and DRB 1*0404 ( P < 0.01). Conclusion This is the largest HLA association study in sporadic PF from the UK to date. There appears to be a difference in PF susceptibility alleles between WB and IA patients, highlighting the importance of racial variation in genetic susceptibility to disease development.