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Thyroid function in hidradenitis suppurativa: a population‐based cross‐sectional study from Denmark
Author(s) -
Miller I. M.,
Vinding G.,
Sørensen H. A.,
Rytgaard H.,
Mogensen U. B.,
Ellervik C.,
Jemec G. B.
Publication year - 2018
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13606
Subject(s) - medicine , thyroid function , endocrinology , body mass index , cross sectional study , thyroid , hidradenitis suppurativa , population , triiodothyronine , obesity , hormone , thyroid disease , thyroid function tests , thyroid stimulating hormone , metabolic syndrome , physiology , disease , pathology , environmental health
Summary Background Hidradenitis suppurativa ( HS ) is a chronic inflammatory disease. Numerous studies have associated HS with obesity, and recently with metabolic syndrome (MetS). Both obesity and MetS are linked with metabolic changes. Thyroid hormones play a central role in metabolism and exert pleiotropic effects on adipogenesis and the basal metabolism of lipids and glucose. We hypothesized that patients with HS have an altered or dysfunctional metabolism expressed as thyroid function. Aim To investigate thyroid function in individuals with HS compared with healthy controls ( HC s). Methods We conducted a retrospective comparative cross‐sectional study using blood samples and questionnaire‐based self‐reported information to assess thyroid function. Results Our study comprised 430 patients in a population‐based HS group, and 20 780 HC s. The age/sex‐adjusted analysis showed a significantly lower level ( P < 0.001) of thyroid‐stimulating hormone ( TSH ) and a significantly higher level ( P < 0.0001) of total triiodothyronine ( tT 3) for the HS compared with the HC group. The age/sex‐adjusted analysis also showed a significant association between clinical hyperthyroidism and HS (an OR = 1.91, 95% CI 1.19–3.07; P = 0.02). When this analysis was adjusted further for the potential confounders of body mass index, smoking and oral contraception, the results remained significant. Conclusion This study suggests that HS is associated with hyperthyroidism. Hyperthyroidism may indicate an altered or dysfunctional metabolism.